Board Thread:Questions and Answers/@comment-2804:431:B700:3599:D022:2FE7:358A:6D2-20180523202338/@comment-35006067-20180524081214

Sierra tries not to punish players (too harshly) for choices they did twenty hours ago of playtime ago. A good example is that she added (small) bonuses in Chapter 4 for having killed the Impaler back in Chapter 2.

So yeah, there are probably no truly irreparable, whole game changing, consequences to whoring Qum. More of a moral choice.